New approaches to elucidate toxic effects in a fish model species, the fathead minnow

Titel:	New approaches to elucidate toxic effects in a fish model species, the fathead minnow
Kategorie:	Oekotoxzentrum - Aktuelle Stunde
Detail:	Gastseminar
Datum:	26. Aug. 2011, 13:30 Uhr - 15:00 Uhr
Ort:	Eawag Dübendorf
	Forum Chriesbach C24
Referenten:	Dr. Natalia Garcia Reyero, Institute for Genomics, Biocomputing and Biotechnology (IGBB) Mississippi State University, Jackson, MS
Leitung:	Dr. Inge Werner, Oekotoxzentrum
Download:	als Kalender-Eintrag

New approaches to elucidate toxic effects in a fish model species, the fathead minnow Ecotoxicology is concerned with understanding how animals are impacted by pollutants in the ecosystem. Recent developments in this area empowered by the widespread availability of functional genomics technologies such as high throughput sequencing, expression profiling, proteomics and metabolomics, have been successful in increasing our understanding of specific mechanism of action and have provided very useful biomarkers for environmental risk assessment. However, the full potential of predictive toxicology can only be achieved by taking a Systems level approach, which integrates these complex multi-level molecular and physiological measurements within a unifying interpretative model. This talk will present a systems biology approach to try to elucidate adverse outcome pathways using the fathead minnow (Pimephales promelas) as a model species.