I am interested in developing alternative in vitro systems which are based on cell lines to replace expensive, time-consuming and ethical questionable animal tests. For my PhD I created a physiologically realistic model of the fish intestine to study its barrier function towards the environment (food & water). Currently for my PostDoc I'm challenging this system with chemicals to better understand uptake and defense mechanisms.
My system is called “fish-gut-on-chip” and combines intestinal cell culture from rainbow trout (Oncorhynchus mykiss) with microchip technology and microfluidic engineering. Non-invasive impedance spectroscopy is used as a powerful tool to monitor barrier functionality in real-time. This project contributes to the development of animal free test systems for chemical risk assessment and water quality monitoring.