Mitarbeitende

Carolin Drieschner

Dr. Carolin Drieschner

Postdoktorandin

Abteilung Umwelttoxikologie

Über mich

I am interested in developing alternative in vitro systems which are based on cell lines to replace expensive, time-consuming and ethical questionable animal tests. For my PhD I created a physiologically realistic model of the fish intestine to study its barrier function towards the environment (food & water). Currently for my PostDoc I'm challenging this system with chemicals to better understand uptake and defense mechanisms.
My system is called “fish-gut-on-chip” and combines intestinal cell culture from rainbow trout (Oncorhynchus mykiss) with microchip technology and microfluidic engineering. Non-invasive impedance spectroscopy is used as a powerful tool to monitor barrier functionality in real-time. This project contributes to the development of animal free test systems for chemical risk assessment and water quality monitoring.

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Projekte

Wir entwickeln experimentelle und theoretische Werkzeuge, um die Vermeidung und Verringerung der Anzahl von Tierversuchen für die Umweltrisikobewertung von Chemikalien voranzutreiben

Alternativen für Tierversuche

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Ausgewählte Publikationen

Drieschner, C.; Minghetti, M.; Wu, S.; Renaud, P.; Schirmer, K. (2017) Ultrathin alumina membranes as scaffold for epithelial cell culture from the intestine of rainbow trout, ACS Applied Materials and Interfaces, 9(11), 9496-9505, doi:10.1021/acsami.7b00705, Institutional Repository
Minghetti, M.; Drieschner, C.; Bramaz, N.; Schug, H.; Schirmer, K. (2017) A fish intestinal epithelial barrier model established from the rainbow trout (Oncorhynchus mykiss) cell line, RTgutGC, Cell Biology and Toxicology, 33(6), 539-555, doi:10.1007/s10565-017-9385-x, Institutional Repository

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Adresse

E-Mail: carolin.drieschner@eawag.ch
Telefon: +41 58 765 5072
Fax: +41 58 765 5802
Adresse: Eawag
Überlandstrasse 133
8600 Dübendorf
Büro: BU E09

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