Mitarbeitende

Ksenia Groh

Dr. Ksenia Groh

Gruppenleiterin

Abteilung Umwelttoxikologie

Über mich

Leiterin der Gruppe Bioanalytik (Tenure-Track)

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Projekte

Das Ziel dieses Projektes ist einen Arbeitsablauf für die gezielte Analytik von phosphoproteinbasierter Signaldynamik in Zebrafischen und Regenbogenforellen Fischzelllinien sowie in Zebrafischembryonen zu etablieren...
Zebrafischembryonen und Zebrafisch Zelllinien haben sich als gutes Modell für die Studie von bioaktiven Verbindungen etabliert...
In collaboration with a high level international expert group we are currently developing a framework to advance adverse outcome pathways...

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Publikationen

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Bakker, E.; Bleiner, D.; Groh, K. (2021) Perspectives and future directions of the division of analytical sciences of the Swiss Chemical Society, Chimia, 75(5), 455-456, doi:10.2533/chimia.2021.455, Institutional Repository
Kirla, K. T.; Erhart, C.; Groh, K. J.; Stadnicka-Michalak, J.; Eggen, R. I. L.; Schirmer, K.; Kraemer, T. (2021) Zebrafish early life stages as alternative model to study 'designer drugs': concordance with mammals in response to opioids, Toxicology and Applied Pharmacology, 419, 115483 (11 pp.), doi:10.1016/j.taap.2021.115483, Institutional Repository
Tierbach, A.; Groh, K. J.; Schoenenberger, R.; Schirmer, K.; Suter, M. J. -F. (2020) Characterization of the mercapturic acid pathway, an important phase II biotransformation route, in a zebrafish embryo cell line, Chemical Research in Toxicology, 33(11), 2863-2871, doi:10.1021/acs.chemrestox.0c00315, Institutional Repository
Tierbach, A.; Groh, K. J.; Schoenenberger, R.; Schirmer, K.; Suter, M. J. -F. (2020) Biotransformation capacity of zebrafish (Danio rerio) early life stages: functionality of the mercapturic acid pathway, Toxicological Sciences, 176(2), 355-365, doi:10.1093/toxsci/kfaa073, Institutional Repository
Tierbach, A.; Groh, K. J.; Schönenberger, R.; Schirmer, K.; Suter, M. J. -F. (2020) LC-APCI(-)-MS determination of 1-chloro-2,4-dinitrobenzene, a model substrate for glutathione S-transferases, Journal of the American Society for Mass Spectrometry, 31, 467-472, doi:10.1021/jasms.9b00116, Institutional Repository
Groh, K. J.; Suter, M. F. -J. (2020) Mass spectrometry in ecotoxicology, In: Sidona, G.; Banoub, J. H.; Di Gioia, M. L. (Eds.), Toxic chemical and biological agents. Detection, diagnosis and health concerns, 93-108, doi:10.1007/978-94-024-2041-8_6, Institutional Repository
Van den Brink, P. J.; Boxall, A. B. A.; Maltby, L.; Brooks, B. W.; Rudd, M. A.; Backhaus, T.; Spurgeon, D.; Verougstraete, V.; Ajao, C.; Ankley, G. T.; Apitz, S. E.; Arnold, K.; Brodin, T.; Cañedo-Argüelles, M.; Chapman, J.; Corrales, J.; Coutellec, M.-A.; Fernandes, T. F.; Fick, J.; Ford, A. T.; Giménez Papiol, G.; Groh, K. J.; Hutchinson, T. H.; Kruger, H.; Kukkonen, J. V. K.; Loutseti, S.; Marshall, S.; Muir, D.; Ortiz-Santaliestra, M. E.; Paul, K. B.; Rico, A.; Rodea-Palomares, I.; Römbke, J.; Rydberg, T.; Segner, H.; Smit, M.; van Gestel, C. A. M.; Vighi, M.; Werner, I.; Zimmer, E. I.; van Wensem, J. (2018) Toward sustainable environmental quality: priority research questions for Europe, Environmental Toxicology and Chemistry, 37(9), 2281-2295, doi:10.1002/etc.4205, Institutional Repository
Kirla, K. T.; Groh, K. J.; Poetzsch, M.; Banote, R. K.; Stadnicka-Michalak, J.; Eggen, R. I. L.; Schirmer, K.; Kraemer, T. (2018) Importance of toxicokinetics to assess the utility of zebrafish larvae as model for psychoactive drug screening using meta-chlorophenylpiperazine (mCPP) as example, Frontiers in Pharmacology, 9, 414 (12 pp.), doi:10.3389/fphar.2018.00414, Institutional Repository
Tierbach, A.; Groh, K. J.; Schönenberger, R.; Schirmer, K.; Suter, M. J. -F. (2018) Glutathione S-transferase protein expression in different life stages of zebrafish (Danio rerio), Toxicological Sciences, 162(2), 702-712, doi:10.1093/toxsci/kfx293, Institutional Repository
Mottaz, H.; Schönenberger, R.; Fischer, S.; Eggen, R. I. L.; Schirmer, K.; Groh, K. J. (2017) Dose-dependent effects of morphine on lipopolysaccharide (LPS)-induced inflammation, and involvement of multixenobiotic resistance (MXR) transporters in LPS efflux in teleost fish, Environmental Pollution, 221, 105-115, doi:10.1016/j.envpol.2016.11.046, Institutional Repository
Hidasi, A. O.; Groh, K. J.; Suter, M. J. -F.; Schirmer, K. (2017) Clobetasol propionate causes immunosuppression in zebrafish (Danio rerio) at environmentally relevant concentrations, Ecotoxicology and Environmental Safety, 138, 16-24, doi:10.1016/j.ecoenv.2016.11.024, Institutional Repository
Kirla, K. T.; Groh, K. J.; Steuer, A. E.; Poetzsch, M.; Banote, R. K.; Stadnicka-Michalak, J.; Eggen, R. I. L.; Schirmer, K.; Kraemer, T. (2016) Zebrafish larvae are insensitive to stimulation by cocaine: importance of exposure route and toxicokinetics, Toxicological Sciences, 154(1), 183-193, doi:10.1093/toxsci/kfw156, Institutional Repository
Oliveira, I. B.; Groh, K. J.; Stadnicka-Michalak, J.; Schönenberger, R.; Beiras, R.; Barroso, C. M.; Langford, K. H.; Thomas, K. V.; Suter, M. J. -F. (2016) Tralopyril bioconcentration and effects on the gill proteome of the Mediterranean mussel Mytilus galloprovincialis, Aquatic Toxicology, 177, 198-210, doi:10.1016/j.aquatox.2016.05.026, Institutional Repository
Groh, K. J.; Dalkvist, T.; Piccapietra, F.; Behra, R.; Suter, M. J. -F.; Schirmer, K. (2015) Critical influence of chloride ions on silver ion-mediated acute toxicity of silver nanoparticles to zebrafish embryos, Nanotoxicology, 9(1), 81-91, doi:10.3109/17435390.2014.893379, Institutional Repository
Di Paolo, C.; Groh, K. J.; Zennegg, M.; Vermeirssen, E. L. M.; Murk, A. J.; Eggen, R. I. L.; Hollert, H.; Werner, I.; Schirmer, K. (2015) Early life exposure to PCB126 results in delayed mortality and growth impairment in the zebrafish larvae, Aquatic Toxicology, 169, 168-178, doi:10.1016/j.aquatox.2015.10.014, Institutional Repository
Groh, K. J.; Carvalho, R. N.; Chipman, J. K.; Denslow, N. D.; Halder, M.; Murphy, C. A.; Roelofs, D.; Rolaki, A.; Schirmer, K.; Watanabe, K. H. (2015) Development and application of the adverse outcome pathway framework for understanding and predicting chronic toxicity: II. a focus on growth impairment in fish, Chemosphere, 120, 778-792, doi:10.1016/j.chemosphere.2014.10.006, Institutional Repository
Groh, K. J.; Carvalho, R. N.; Chipman, J. K.; Denslow, N. D.; Halder, M.; Murphy, C. A.; Roelofs, D.; Rolaki, A.; Schirmer, K.; Watanabe, K. H. (2015) Development and application of the adverse outcome pathway framework for understanding and predicting chronic toxicity: I. challenges and research needs in ecotoxicology, Chemosphere, 120, 764-777, doi:10.1016/j.chemosphere.2014.09.068, Institutional Repository

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Adresse

E-Mail: ksenia.groh@eawag.ch
Telefon: +41 58 765 5182
Fax: +41 58 765 5802
Adresse: Eawag
Überlandstrasse 133
8600 Dübendorf
Büro: BU E03

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Experte für

Molekulare Ökotoxikologie, Aquatische Ökotoxikologie, Proteomik, Mikroverunreinigungen, Endokrine Disruptoren, Bioanalytik

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Forschungsgruppen

Bioanalytik

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Forschungsschwerpunkte

chronische Toxizität, molekulare Mechanismen der Toxizität, massenspektrometrie-basierte Proteomik, Adverse Outcome Pathway

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