Staff

Carolin Drieschner

Dr. Carolin Drieschner

Postdoctoral Scientist

Department Environmental Toxicology

About Me

I am interested in developing alternative in vitro systems which are based on cell lines to replace expensive, time-consuming and ethical questionable animal tests. For my PhD I created a physiologically realistic model of the fish intestine to study its barrier function towards the environment (food & water). Currently for my PostDoc I'm challenging this system with chemicals to better understand uptake and defense mechanisms.
My system is called “fish-gut-on-chip” and combines intestinal cell culture from rainbow trout (Oncorhynchus mykiss) with microchip technology and microfluidic engineering. Non-invasive impedance spectroscopy is used as a powerful tool to monitor barrier functionality in real-time. This project contributes to the development of animal free test systems for chemical risk assessment and water quality monitoring.

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Projects

We develop experimental and computational tools to aid in the replacement and reduction of animal testing for environmental risk assessment, specifically for assessments using fish

Alternatives to animals testing

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Curriculum Vitae

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Selected publications

Drieschner, C.; Minghetti, M.; Wu, S.; Renaud, P.; Schirmer, K. (2017) Ultrathin alumina membranes as scaffold for epithelial cell culture from the intestine of rainbow trout, ACS Applied Materials and Interfaces, 9(11), 9496-9505, doi:10.1021/acsami.7b00705, Institutional Repository
Minghetti, M.; Drieschner, C.; Bramaz, N.; Schug, H.; Schirmer, K. (2017) A fish intestinal epithelial barrier model established from the rainbow trout (Oncorhynchus mykiss) cell line, RTgutGC, Cell Biology and Toxicology, 33(6), 539-555, doi:10.1007/s10565-017-9385-x, Institutional Repository

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Address

E-Mail: carolin.drieschner@eawag.ch
Phone: +41 58 765 5072
Fax: +41 58 765 5802
Address: Eawag
Überlandstrasse 133
8600 Dübendorf
Office: BU E09

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Research Focus

Aquatic ecotoxicology, In vitro cell culture, Fish cell lines, Organs-on-chips, Microfluidics, Ultrathin nanoporous membranes, Impedance based toxicity testing

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