Staff

Hannah Schug

Dr. Hannah Schug

Postdoctoral Scientist

Department Environmental Toxicology

About Me

I am interested in developing methods to examine the effect of potential, environmental contaminants on aquatic organisms, ranging from low (microbial communities) to high trophic levels (fish). In my current research project I work with an intestinal fish cell line (RTgutGC) originally isolated from rainbow trout (Oncorhynchus mykiss).
I aim to characterize the barrier function of these epithelial cells in two different directions: 1. their physical barrier properties and the permeation of organic substances and 2. their immunological barrier function, including basic molecular characterization and response to immune stimuli and toxicants. With this research I would like to contribute to the establishment of a unique model for a variety of applications reducing the need of fish.

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Projects

We develop experimental and computational tools to aid in the replacement and reduction of animal testing for environmental risk assessment, specifically for assessments using fish
Cellular epithelia are gate keepers that regulate the interaction of an organism with its surrounding environment...
Quantification of chemical toxicity continues to be based mainly on measurements of external exposure. Yet, in order to understand, interpret and extrapolate toxic effects, using internal concentrations of chemicals is more suitable...

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Curriculum Vitae

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Selected publications

Schug, H.; Maner, J.; Hülskamp, M.; Begnaud, F.; Debonneville, C.; Berthaud, F.; Gimeno, S.; Schirmer, K. (2019) Extending the concept of predicting fish acute toxicity in vitro to the intestinal cell line RTgutGC, ALTEX: Alternatives to Animal Experimentation, (9 pp.), doi:10.14573/altex.1905032, Institutional Repository
Drieschner, C.; Vo, N. T. K.; Schug, H.; Burkard, M.; Bols, N. C.; Renaud, P.; Schirmer, K. (2019) Improving a fish intestinal barrier model by combining two rainbow trout cell lines: epithelial RTgutGC and fibroblastic RTgutF, Cytotherapy, doi:10.1007/s10616-019-00327-0, Institutional Repository
Schug, H.; Yue, Y.; Krese, R.; Fischer, S.; Kortner, T. M.; Schirmer, K. (2019) Time- and concentration-dependent expression of immune and barrier genes in the RTgutGC fish intestinal model following immune stimulation, Fish and Shellfish Immunology, 88, 308-317, doi:10.1016/j.fsi.2019.02.036, Institutional Repository
Schug, H.; Begnaud, F.; Debonneville, C.; Berthaud, F.; Gimeno, S.; Schirmer, K. (2018) TransFEr: a new device to measure the transfer of volatile and hydrophobic organic chemicals across an in vitro intestinal fish cell barrier, Analytical Methods, 10(36), 4394-4403, doi:10.1039/C8AY01253A, Institutional Repository
Minghetti, M.; Drieschner, C.; Bramaz, N.; Schug, H.; Schirmer, K. (2017) A fish intestinal epithelial barrier model established from the rainbow trout (Oncorhynchus mykiss) cell line, RTgutGC, Cell Biology and Toxicology, 33(6), 539-555, doi:10.1007/s10565-017-9385-x, Institutional Repository
Sigg, L.; Behra, R.; Groh, K.; Isaacson, C.; Odzak, N.; Piccapietra, F.; Röhder, L.; Schug, H.; Yue, Y.; Schirmer, K. (2014) Chemical aspects of nanoparticle ecotoxicology, Chimia, 68(11), 806-811, doi:10.2533/chimia.2014.806, Institutional Repository
Schug, H.; Isaacson, C. W.; Sigg, L.; Ammann, A. A.; Schirmer, K. (2014) Effect of TiO2 nanoparticles and UV radiation on extracellular enzyme activity of intact heterotrophic biofilms, Environmental Science and Technology, 48(19), 11620-11628, doi:10.1021/es502620e, Institutional Repository

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Address

E-Mail: hannah.schug@eawag.ch
Phone: +41 58 765 5599
Fax: +41 58 765 5802
Address: Eawag
Überlandstrasse 133
8600 Dübendorf
Office: BU E08

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Research Focus

Aquatic Ecotoxicology, alternatives to animal testing, cell culture, fish cell lines, bioaccumulation

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