Staff

Julita Stadnicka

Dr. Julita Stadnicka

Postdoctoral Scientist

Department Environmental Toxicology

About Me

Research interests

  • Predicting chemical biotransformation in animals based on in vitro experiments with different cell lines.
  • Alternatives to experimental animals for chemical risk assessment: combining in vitro experiments on cell lines with modeling approaches to lead to a new strategy for screening chemicals for toxicity and predicting effects on animals.
  • Mechanistic effect models for ecological risk assessment of chemicals. This project was a part of of Marie Curie Initial Training Network (CREAM, Fish-1)

Awards

  • Young Scientist Award for the best platform presentation at the 23rd Annual Meeting of the Society of Environmental Toxicology and Chemistry (SETAC Europe), Glasgow 2013.
  • Young Scientist Award for the best oral presentation at 1st European Conference on the Replacement, Reduction and Refinement of Animal Experiments in Ecotoxicology, Dübendorf 2012.
  • University Top 12 award, Wroclaw 2010.
  • Department Best Graduate Award, Wroclaw 2010.
  • Best presentation award at 7th Student Scientific Conference, Wroclaw 2009.

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Projects

Environmental risk assessment is essential but often relies on ethically controversial and expensive methods...
We develop experimental and computational tools to aid in the replacement and reduction of animal testing for environmental risk assessment, specifically for assessments using fish

Alternatives to animals testing

The project, funded by 3R Research Foundation Switzerland (3R-Project 145-15) aims to develop an animal-free alternative to replace experiments with fish for quantifying the impact of chemicals on fish growth at early life stages...
Quantification of chemical toxicity continues to be based mainly on measurements of external exposure. Yet, in order to understand, interpret and extrapolate toxic effects, using internal concentrations of chemicals is more suitable...

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Curriculum Vitae

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Selected publications

Stadnicka-Michalak, J.; Schirmer, K. (2019) In vitro-in vivo extrapolation to predict bioaccumulation and toxicity of chemicals in fish using physiologically based toxicokinetic models, doi:10.1007/7653_2019_34, Institutional Repository
Zhang, J.; Empl, M. T.; Schneider, M.; Schröder, B.; Stadnicka-Michalak, J.; Breves, G.; Steinberg, P.; Sturla, S. J. (2019) Gut microbial transformation of the dietary mutagen MeIQx may reduce exposure levels without altering intestinal transport, Toxicology in Vitro, 59, 238-245, doi:10.1016/j.tiv.2019.04.004, Institutional Repository
Stadnicka-Michalak, J.; Weiss, F. T.; Fischer, M.; Tanneberger, K.; Schirmer, K. (2018) Biotransformation of benzo [a] pyrene by three rainbow trout (Onchorhynchus mykiss) cell lines and extrapolation to derive a fish bioconcentration factor, Environmental Science and Technology, 52(5), 3091-3100, doi:10.1021/acs.est.7b04548, Institutional Repository
Kirla, K. T.; Groh, K. J.; Poetzsch, M.; Banote, R. K.; Stadnicka-Michalak, J.; Eggen, R. I. L.; Schirmer, K.; Kraemer, T. (2018) Importance of toxicokinetics to assess the utility of zebrafish larvae as model for psychoactive drug screening using meta-chlorophenylpiperazine (mCPP) as example, Frontiers in Pharmacology, 9, 414 (12 pp.), doi:10.3389/fphar.2018.00414, Institutional Repository
Stadnicka-Michalak, J.; Knöbel, M.; Županič, A.; Schirmer, K. (2018) A validated algorithm for selecting non-toxic chemical concentrations, ALTEX: Alternatives to Animal Experimentation, 35(1), 37-50, doi:10.14573/altex.1701231, Institutional Repository
Isaacson, C. W.; Sigg, L.; Ammann, A. A.; Stadnicka-Michalak, J.; Schirmer, K. (2017) Interactions of TiO2 nanoparticles and the freshwater nematode Plectus aquatilis: particle properties, kinetic parameters and bioconcentration factors, Environmental Science: Nano, 4(3), 712-719, doi:10.1039/c6en00495d, Institutional Repository
Kirla, K. T.; Groh, K. J.; Steuer, A. E.; Poetzsch, M.; Banote, R. K.; Stadnicka-Michalak, J.; Eggen, R. I. L.; Schirmer, K.; Kraemer, T. (2016) Zebrafish larvae are insensitive to stimulation by cocaine: importance of exposure route and toxicokinetics, Toxicological Sciences, 154(1), 183-193, doi:10.1093/toxsci/kfw156, Institutional Repository
Oliveira, I. B.; Groh, K. J.; Stadnicka-Michalak, J.; Schönenberger, R.; Beiras, R.; Barroso, C. M.; Langford, K. H.; Thomas, K. V.; Suter, M. J. -F. (2016) Tralopyril bioconcentration and effects on the gill proteome of the Mediterranean mussel Mytilus galloprovincialis, Aquatic Toxicology, 177, 198-210, doi:10.1016/j.aquatox.2016.05.026, Institutional Repository
Stadnicka-Michalak, J.; Schirmer, K.; Ashauer, R. (2015) Toxicology across scales: cell population growth in vitro predicts reduced fish growth, Science Advances, 1(7), 1-8, doi:10.1126/sciadv.1500302, Institutional Repository
Stadnicka-Michalak, J.; Tanneberger, K.; Schirmer, K.; Ashauer, R. (2014) Measured and modeled toxicokinetics in cultured fish cells and application to in vitro - in vivo toxicity extrapolation, PLoS One, 9(3), e92303 (10 pp.), doi:10.1371/journal.pone.0092303, Institutional Repository
Stadnicka, J.; Schirmer, K.; Ashauer, R. (2012) Predicting concentrations of organic chemicals in fish by using toxicokinetic models, Environmental Science and Technology, 46(6), 3273-3280, doi:10.1021/es2043728, Institutional Repository
Ashauer, R.; Agatz, A.; Albert, C.; Ducrot, V.; Galic, N.; Hendriks, J.; Jager, T.; Kretschmann, A.; O'Connor, I.; Rubach, M. N.; Nyman, A.-M.; Schmitt, W.; Stadnicka, J.; Van den Brink, P. J.; Preuss, T. G. (2011) Toxicokinetic-toxicodynamic modeling of quantal and graded sublethal endpoints: a brief discussion of concepts, Environmental Toxicology and Chemistry, 30(11), 2519-2524, doi:10.1002/etc.639, Institutional Repository

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Address

E-Mail: julita.stadnicka@eawag.ch
Phone: +41 58 765 5533
Fax: +41 58 765 5802
Address: Eawag
Überlandstrasse 133
8600 Dübendorf
Office: BU E08

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