Head of Systems Biology Group
The Systems Biology group was formed in 2014 and studies how the use of bioinformatics and biologicial network modeling can help predict the effects of environmental stressors on aquatic species and the aquatic ecosystem.
My current research interest fall within two general themes: determining the molecular mechanism of environmental stress and quantitative prediction of physiologically and ecologically relevant outcomes based on low- and high-throughput molecular assays. A mechanistic understanding of cellular processes that leads from molecular initiating events to an adverse outcome will aid in establishing sets of stress specific biomarkers, leading to cheaper biomarker-based molecular assays that could be used in ecosystems monitoring. Understanding of the toxic mechanisms of two individual stressors will lead to better understanding of the interactions between them and the prediction of synergistic and antagonistic effects. Validated mechanistic toxicological models can be used to quantitatively predict adverse outcome of environmental exposures, based on either biomarker or high-throughput omics measurements.
While excellent and rigorous research is necessary to move science forward, it is not enough to achieve the full impact scientific discoveries should have on our society. Equally important are positive interactions with policy makers, the industry and the general public. In this respect, I have in the past given and organized several public talk, one of which you can see here: Biological Complexity at TEDxLjubljana.