Abteilung Umweltchemie

Extracellular Enzymes

Various aquatic organisms produce extracellular biomolecules, e.g., enzymes to catalyze reactions, chelators to transport metals, or toxins to fight competitors. Quantifying the environmental stability of these biomolecules is directly linked to a better understanding of environmental fluxes of organic matter and metals. However, our understanding of linking molecular changes to inactivation of biomacromolecules is currently limited and our research focuses on these blind spots. Our current project on environmental photoinactivation of extracellular enzymes is funded by the Swiss National Science Foundation (SNSF project, Oct-2015 to 2018).

Christine Egli aims to correlate site-specific damage of molecular changes to loss of enzyme activity (e.g., of phosphatase, aminopeptidase, glucosidase). The work involves steady-state photolysis, proteomics techniques, high-resolution mass spectrometry, and enzymology of synthetic and natural samples.