Department Environmental Chemistry

Stability and fate of bio-& macromolecules

The research group Bio-&-Macromolecules investigates the stability and fate processes of biomolecules and macromolecular pollutants in aquatic systems. We aim to connect molecular transformation reactions to changes in the functionality of these large compounds. Therefore, we incorporate molecular biology tools into our environmental chemistry research.

We investigate the transformation mechanisms of extracellular biomolecules, their monomeric building blocks as well as macromolecular pollutants in aquatic systems. Here, we establish transformation rates and product formation in controlled and simulated natural systems to determine the compound’s mobility (e.g., partitioning behavior) and stability (e.g., biotic and photochemical reactivity). From there, we aim to connect molecular changes in the three-dimensional structure to changes of the compound’s function (e.g., toxicity, inhibition, catalysis). Our work requires to further develop state-of-the art analytical chemistry in combination with molecular tools, including techniques from proteomics and enzymology.

Contact

Dr. Elisabeth JanssenSenior Scientist / group leaderTel. +41 58 765 5428Send Mail

PhD's

Caroline DavisPhD StudentTel. +41 58 765 5450Send Mail
Christine EgliPhD studentTel. +41 58 765 5387Send Mail
Regiane Sanches NatumiDoktorandin/PhD student/DoctoranteTel. +41 58 765 6417Send Mail

Current projects

Various aquatic organisms produce extracellular biomolecules, e.g., enzymes to catalyze reactions, chelators to transport metals, or toxins to fight competitors...
Our research on fate of pharmaceuticals is motivated by investigating transformation pathways and kinetics to better understand the lifetime of such biologically active compounds in our freshwater Systems...
Our research is part of an EU International Training Network (ITN) focusing on Natural Toxins and Drinking Water Quality: From Source to Tap (NaToxAq)