Mitarbeitende

Ksenia Groh

Dr. Ksenia Groh

Gruppenleiterin

Abteilung Umwelttoxikologie

Über mich

Leiterin der Gruppe Bioanalytik (Tenure-Track)

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Projekte

Globale und gezielte Proteomik Analysen liefern Einblicke in die molekularen Mechanismen der Toxizität.
In diesem Projekt werden GST-Enzyme in alternativen Testmodellen wie Zebrafischembryonen und Zelllinien untersucht.
In collaboration with a high level international expert group we are currently developing a framework to advance adverse outcome pathways...

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Publikationen

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Wang, Z.; Wiesinger, H.; Groh, K. (2021) Time to reveal chemical identities of polymers and UVCBs, Environmental Science and Technology, 55(21), 14473-14476, doi:10.1021/acs.est.1c05620, Institutional Repository
Maffini, M. V.; Geueke, B.; Groh, K.; Carney Almroth, B.; Muncke, J. (2021) Role of epidemiology in risk assessment: a case study of five ortho-phthalates, Environmental Health, 20, 114 (14 pp.), doi:10.1186/s12940-021-00799-8, Institutional Repository
Bakker, E.; Bleiner, D.; Groh, K. (2021) Perspectives and future directions of the division of analytical sciences of the Swiss Chemical Society, Chimia, 75(5), 455-456, doi:10.2533/chimia.2021.455, Institutional Repository
Kirla, K. T.; Erhart, C.; Groh, K. J.; Stadnicka-Michalak, J.; Eggen, R. I. L.; Schirmer, K.; Kraemer, T. (2021) Zebrafish early life stages as alternative model to study 'designer drugs': concordance with mammals in response to opioids, Toxicology and Applied Pharmacology, 419, 115483 (11 pp.), doi:10.1016/j.taap.2021.115483, Institutional Repository
Tierbach, A.; Groh, K. J.; Schoenenberger, R.; Schirmer, K.; Suter, M. J. -F. (2020) Characterization of the mercapturic acid pathway, an important phase II biotransformation route, in a zebrafish embryo cell line, Chemical Research in Toxicology, 33(11), 2863-2871, doi:10.1021/acs.chemrestox.0c00315, Institutional Repository
Tierbach, A.; Groh, K. J.; Schoenenberger, R.; Schirmer, K.; Suter, M. J. -F. (2020) Biotransformation capacity of zebrafish (Danio rerio) early life stages: functionality of the mercapturic acid pathway, Toxicological Sciences, 176(2), 355-365, doi:10.1093/toxsci/kfaa073, Institutional Repository
Tierbach, A.; Groh, K. J.; Schönenberger, R.; Schirmer, K.; Suter, M. J. -F. (2020) LC-APCI(-)-MS determination of 1-chloro-2,4-dinitrobenzene, a model substrate for glutathione S-transferases, Journal of the American Society for Mass Spectrometry, 31, 467-472, doi:10.1021/jasms.9b00116, Institutional Repository
Groh, K. J.; Suter, M. F. -J. (2020) Mass spectrometry in ecotoxicology, In: Sidona, G.; Banoub, J. H.; Di Gioia, M. L. (Eds.), Toxic chemical and biological agents. Detection, diagnosis and health concerns, 93-108, doi:10.1007/978-94-024-2041-8_6, Institutional Repository
Van den Brink, P. J.; Boxall, A. B. A.; Maltby, L.; Brooks, B. W.; Rudd, M. A.; Backhaus, T.; Spurgeon, D.; Verougstraete, V.; Ajao, C.; Ankley, G. T.; Apitz, S. E.; Arnold, K.; Brodin, T.; Cañedo-Argüelles, M.; Chapman, J.; Corrales, J.; Coutellec, M.-A.; Fernandes, T. F.; Fick, J.; Ford, A. T.; Giménez Papiol, G.; Groh, K. J.; Hutchinson, T. H.; Kruger, H.; Kukkonen, J. V. K.; Loutseti, S.; Marshall, S.; Muir, D.; Ortiz-Santaliestra, M. E.; Paul, K. B.; Rico, A.; Rodea-Palomares, I.; Römbke, J.; Rydberg, T.; Segner, H.; Smit, M.; van Gestel, C. A. M.; Vighi, M.; Werner, I.; Zimmer, E. I.; van Wensem, J. (2018) Toward sustainable environmental quality: priority research questions for Europe, Environmental Toxicology and Chemistry, 37(9), 2281-2295, doi:10.1002/etc.4205, Institutional Repository
Kirla, K. T.; Groh, K. J.; Poetzsch, M.; Banote, R. K.; Stadnicka-Michalak, J.; Eggen, R. I. L.; Schirmer, K.; Kraemer, T. (2018) Importance of toxicokinetics to assess the utility of zebrafish larvae as model for psychoactive drug screening using meta-chlorophenylpiperazine (mCPP) as example, Frontiers in Pharmacology, 9, 414 (12 pp.), doi:10.3389/fphar.2018.00414, Institutional Repository
Tierbach, A.; Groh, K. J.; Schönenberger, R.; Schirmer, K.; Suter, M. J. -F. (2018) Glutathione S-transferase protein expression in different life stages of zebrafish (Danio rerio), Toxicological Sciences, 162(2), 702-712, doi:10.1093/toxsci/kfx293, Institutional Repository
Mottaz, H.; Schönenberger, R.; Fischer, S.; Eggen, R. I. L.; Schirmer, K.; Groh, K. J. (2017) Dose-dependent effects of morphine on lipopolysaccharide (LPS)-induced inflammation, and involvement of multixenobiotic resistance (MXR) transporters in LPS efflux in teleost fish, Environmental Pollution, 221, 105-115, doi:10.1016/j.envpol.2016.11.046, Institutional Repository
Hidasi, A. O.; Groh, K. J.; Suter, M. J. -F.; Schirmer, K. (2017) Clobetasol propionate causes immunosuppression in zebrafish (Danio rerio) at environmentally relevant concentrations, Ecotoxicology and Environmental Safety, 138, 16-24, doi:10.1016/j.ecoenv.2016.11.024, Institutional Repository
Kirla, K. T.; Groh, K. J.; Steuer, A. E.; Poetzsch, M.; Banote, R. K.; Stadnicka-Michalak, J.; Eggen, R. I. L.; Schirmer, K.; Kraemer, T. (2016) Zebrafish larvae are insensitive to stimulation by cocaine: importance of exposure route and toxicokinetics, Toxicological Sciences, 154(1), 183-193, doi:10.1093/toxsci/kfw156, Institutional Repository
Oliveira, I. B.; Groh, K. J.; Stadnicka-Michalak, J.; Schönenberger, R.; Beiras, R.; Barroso, C. M.; Langford, K. H.; Thomas, K. V.; Suter, M. J. -F. (2016) Tralopyril bioconcentration and effects on the gill proteome of the Mediterranean mussel Mytilus galloprovincialis, Aquatic Toxicology, 177, 198-210, doi:10.1016/j.aquatox.2016.05.026, Institutional Repository
Groh, K. J.; Dalkvist, T.; Piccapietra, F.; Behra, R.; Suter, M. J. -F.; Schirmer, K. (2015) Critical influence of chloride ions on silver ion-mediated acute toxicity of silver nanoparticles to zebrafish embryos, Nanotoxicology, 9(1), 81-91, doi:10.3109/17435390.2014.893379, Institutional Repository
Di Paolo, C.; Groh, K. J.; Zennegg, M.; Vermeirssen, E. L. M.; Murk, A. J.; Eggen, R. I. L.; Hollert, H.; Werner, I.; Schirmer, K. (2015) Early life exposure to PCB126 results in delayed mortality and growth impairment in the zebrafish larvae, Aquatic Toxicology, 169, 168-178, doi:10.1016/j.aquatox.2015.10.014, Institutional Repository
Groh, K. J.; Carvalho, R. N.; Chipman, J. K.; Denslow, N. D.; Halder, M.; Murphy, C. A.; Roelofs, D.; Rolaki, A.; Schirmer, K.; Watanabe, K. H. (2015) Development and application of the adverse outcome pathway framework for understanding and predicting chronic toxicity: II. a focus on growth impairment in fish, Chemosphere, 120, 778-792, doi:10.1016/j.chemosphere.2014.10.006, Institutional Repository
Groh, K. J.; Carvalho, R. N.; Chipman, J. K.; Denslow, N. D.; Halder, M.; Murphy, C. A.; Roelofs, D.; Rolaki, A.; Schirmer, K.; Watanabe, K. H. (2015) Development and application of the adverse outcome pathway framework for understanding and predicting chronic toxicity: I. challenges and research needs in ecotoxicology, Chemosphere, 120, 764-777, doi:10.1016/j.chemosphere.2014.09.068, Institutional Repository

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Adresse

E-Mail: ksenia.groh@eawag.ch
Telefon: +41 58 765 5182
Fax: +41 58 765 5802
Adresse: Eawag
Überlandstrasse 133
8600 Dübendorf
Büro: BU E03

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Experte für

Molekulare Ökotoxikologie, Aquatische Ökotoxikologie, Proteomik, Mikroverunreinigungen, Endokrine Disruptoren, Bioanalytik

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Forschungsgruppen

Bioanalytik

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Forschungsschwerpunkte

chronische Toxizität, molekulare Mechanismen der Toxizität, massenspektrometrie-basierte Proteomik, Adverse Outcome Pathway

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