Department Surface Waters - Research and Management

Swiss river resistome: reservoirs, fate and exposure

Treated wastewater is a point source of antibiotic resistant bacteria, as normal waste water treatment facilities do not remove all resistant bacteria. Resistant bacteria released into streams and rivers from treated wastewater represent a risk for humans. In order to assess this risk we need to understand how antibiotic resistance spreads in bodies of water and how stable it is in this medium.

This project is focused on how this resistance behaves and where humans may come into contact with it. We are looking at which bacteria bearing which kinds of resistance pass into Swiss streams and rivers in this way and where they can be found. We are paying special attention to aquatic animals, sediments and so-called biofilms: layers of bacteria on the surface of water sediment. We are also recording the distances over which resistance is transported and how robust it is. This information will enable us to develop models to predict the resistance burden of flowing waterways along their courses. The mission is to identify places in which humans could come into contact with resistance from waste water treatment facilities. Our data and models will provide a basis for decisions and actions that will make it possible to control the spread of antibiotic resistance through flowing waterways.


Research papers

Lee, J.; Beck, K.; Bürgmann, H. (2022) Wastewater bypass is a major temporary point-source of antibiotic resistance genes and multi-resistance risk factors in a Swiss river, Water Research, 208, 117827 (12 pp.), doi:10.1016/j.watres.2021.117827, Institutional Repository
Lee, J.; Ju, F.; Maile-Moskowitz, A.; Beck, K.; Maccagnan, A.; McArdell, C. S.; Dal Molin, M.; Fenicia, F.; Vikesland, P.; Pruden, A.; Stamm, C.; Bürgmann, H. (2021) Unraveling the riverine antibiotic resistome: the downstream fate of anthropogenic inputs, Water Research, 197, 117050 (12 pp.), doi:10.1016/j.watres.2021.117050, Institutional Repository
Yuan, L.; Wang, Y.; Zhang, L.; Palomo, A.; Zhou, J.; Smets, B. F.; Bürgmann, H.; Ju, F. (2021) Pathogenic and indigenous denitrifying bacteria are transcriptionally active and key multi-antibiotic-resistant players in wastewater treatment plants, Environmental Science and Technology, 55(15), 10862-10874, doi:10.1021/acs.est.1c02483, Institutional Repository
Marano, R. B. M.; Fernandes, T.; Manaia, C. M.; Nunes, O.; Morrison, D.; Berendonk, T. U.; Kreuzinger, N.; Telson, T.; Corno, G.; Fatta-Kassinos, D.; Bürgmann, H.; Beck, K.; Cytryn, E. (2020) A global multinational survey of cefotaxime-resistant coliforms in urban wastewater treatment plants, Environment International, 144, 106035 (11 pp.), doi:10.1016/j.envint.2020.106035, Institutional Repository
Ju, F.; Beck, K.; Yin, X.; Maccagnan, A.; McArdell, C. S.; Singer, H. P.; Johnson, D. R.; Zhang, T.; Bürgmann, H. (2019) Wastewater treatment plant resistomes are shaped by bacterial composition, genetic exchange, and upregulated expression in the effluent microbiomes, ISME Journal, 13(2), 346-360, doi:10.1038/s41396-018-0277-8, Institutional Repository
Yang, L.; Wen, Q.; Zhao, Y.; Chen, Z.; Wang, Q.; Bürgmann, H. (2019) New insight into effect of antibiotics concentration and process configuration on the removal of antibiotics and relevant antibiotic resistance genes, Journal of Hazardous Materials, 373, 60-66, doi:10.1016/j.jhazmat.2019.03.060, Institutional Repository

Reviews / Perspectives

Bürgmann, H.; Frigon, D.; Gaze, W.; Manaia, C.; Pruden, A.; Singer, A. C.; Smets, B.; Zhang, T. (2018) Water and sanitation: an essential battlefront in the war on antimicrobial resistance, FEMS Microbiology Ecology, 94(9), fiy101 (14 pp.), doi:10.1093/femsec/fiy101, Institutional Repository
Vikesland, P. J.; Pruden, A.; Alvarez, P. J. J.; Aga, D. S.; Buergmann, H.; Li, X.; Manaia, C. M.; Nambi, I. M.; Wigginton, K. R.; Zhang, T.; Zhu, Y.-G. (2017) Towards a comprehensive strategy to mitigate dissemination of environmental sources of antibiotic resistance, Environmental Science and Technology, 51(22), 13061-13069, doi:10.1021/acs.est.7b03623, Institutional Repository

PhD thesis

Lee, Jangwoo (2021) Tracking anthropogenic footprints of antimicrobial resistance in the river system: A Swiss perspective