Wastewater

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   0 => Snowflake\Publications\Domain\Model\Publicationprototypepersistent entity (uid=34703, pid=124)
      originalId => protected34703 (integer)
      authors => protected'Baumgartner, S.; Salvisberg, M.; Schmidhalter, P.; Julian,&nb
         sp;T. R.; Ort, C.; Singer, H.' (120 chars)
      title => protected'Insights into respiratory illness at the population level through parallel a
         nalysis of pharmaceutical and viral markers in wastewater' (133 chars)
      journal => protected'Nature Water' (12 chars)
      year => protected2025 (integer)
      volume => protected3 (integer)
      issue => protected'' (0 chars)
      startpage => protected'580' (3 chars)
      otherpage => protected'589' (3 chars)
      categories => protected'' (0 chars)
      description => protected'Wastewater as a medium contains information on both circulating pathogens an
         d drug consumption at the population level. This study combines tracking of 
         respiratory viruses and quantification of pharmaceuticals as untargeted indi
         cators of symptoms related to acute respiratory infections and influenza-lik
         e illnesses such as coughing, fever and pain. From January 2021 to June 2024
         , raw wastewater samples from ten locations covering 23% of the Swiss popula
         tion were analysed. This encompassed 15 pharmaceuticals and four priority re
         spiratory viruses including severe acute respiratory syndrome coronavirus vi
         rus-2 (SARS-CoV-2), respiratory syncytial virus (RSV), influenza A and influ
         enza B viruses. The pharmaceutical compounds dextromethorphan, pheniramine, 
         clarithromycin, acetaminophen and codeine showed a strong correlation with r
         espiratory virus loads in wastewater. This enabled the estimation of pathoge
         n-specific and cumulative symptom treatment in the population. In 2021 and 2
         024, notable increases in pharmaceutical loads without corresponding increas
         es in viral loads signalled high community symptoms linked to unsurveilled p
         athogens. This study demonstrates that pharmaceutical surveillance can infor
         m respiratory disease burden and highlights the value of integrated surveill
         ance for assessing emerging public health threats beyond those routinely mon
         itored.' (1375 chars)
      serialnumber => protected'' (0 chars)
      doi => protected'10.1038/s44221-025-00437-4' (26 chars)
      uid => protected34703 (integer)
      _localizedUid => protected34703 (integer)modified
      _languageUid => protectedNULL
      _versionedUid => protected34703 (integer)modified
      pid => protected124 (integer)
   1 => Snowflake\Publications\Domain\Model\Publicationprototypepersistent entity (uid=35350, pid=124)
      originalId => protected35350 (integer)
      authors => protected'Pitton, M.; McLeod, R. E.; Caduff, L.; Dauletova, A
         .; de Korne-Elenbaas, J.; Gan, C.; Hablützel, C.; Holschneid
         er, A.; Kang, S.; Loustalot, G.; Schmidhalter, P.; Schne
         ider, L.; Wettlauffer, A.; Yordanova, D.; Julian, T.&nbs
         p;R.; Ort, C.' (322 chars)
      title => protected'A six-plex digital PCR assay for monitoring respiratory viruses in wastewate
         r' (77 chars)
      journal => protected'Nature Water' (12 chars)
      year => protected2025 (integer)
      volume => protected3 (integer)
      issue => protected'' (0 chars)
      startpage => protected'1174' (4 chars)
      otherpage => protected'1186' (4 chars)
      categories => protected'' (0 chars)
      description => protected'Wastewater surveillance can track trends in multiple pathogens simultaneousl
         y by leveraging efficient laboratory processing. In Switzerland, wastewater 
         surveillance of four respiratory pathogens is conducted at 14 locations repr
         esenting 2.3 million people. Trends in respiratory diseases are tracked usin
         g a six-plex digital PCR assay targeting influenza A, influenza B, respirato
         ry syncytial virus and SARS-CoV-2 N1 and N2 regions and murine hepatitis vir
         us for recovery efficiency control. Wastewater data were integrated with dis
         ease data from two reporting systems, and comparisons from July 2023 to July
          2024 showed strong agreement for most targets. Lower correspondence for inf
         luenza B highlighted challenges in tracking disease dynamics during seasons 
         without pronounced outbreaks. Wastewater monitoring further revealed that ta
         rgeting N1 or N2 led to divergent estimates of SARS-CoV-2 loads, highlightin
         g the impact of mutations in assay target regions. The study emphasizes the 
         importance of an integrated wastewater monitoring programme as a complementa
         ry tool for public health surveillance, demonstrating clear concordance with
          clinical data.' (1155 chars)
      serialnumber => protected'' (0 chars)
      doi => protected'10.1038/s44221-025-00503-x' (26 chars)
      uid => protected35350 (integer)
      _localizedUid => protected35350 (integer)modified
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      _versionedUid => protected35350 (integer)modified
      pid => protected124 (integer)
   2 => Snowflake\Publications\Domain\Model\Publicationprototypepersistent entity (uid=34992, pid=124)
      originalId => protected34992 (integer)
      authors => protected'Ruan, C.; Vinod, D. P.; Johnson, D. R.' (63 chars)
      title => protected'Phage-mediated peripheral kill-the-winner facilitates the maintenance of cos
         tly antibiotic resistance' (101 chars)
      journal => protected'Nature Communications' (21 chars)
      year => protected2025 (integer)
      volume => protected16 (integer)
      issue => protected'1' (1 chars)
      startpage => protected'5839 (13 pp.)' (13 chars)
      otherpage => protected'' (0 chars)
      categories => protected'' (0 chars)
      description => protected'The persistence of antibiotic resistant (AR) bacteria in the absence of anti
         biotic pressure raises a paradox regarding the fitness costs associated with
          antibiotic resistance. These fitness costs should slow the growth of AR bac
         teria and cause them to be displaced by faster-growing antibiotic sensitive 
         (AS) counterparts. Yet, even in the absence of antibiotic pressure, slower-g
         rowing AR bacteria can persist for prolonged periods of time. Here, we demon
         strate a mechanism that can explain this apparent paradox. We hypothesize th
         at lytic phage can modulate bacterial spatial organization to facilitate the
          persistence of slower-growing AR bacteria. Using surface-associated growth 
         experiments with the bacterium <em>Escherichia coli</em> in conjunction with
          individual-based computational simulations, we show that phage disproportio
         nately lyse the faster-growing AS counterpart cells located at the biomass p
         eriphery via a peripheral kill-the-winner dynamic. This enables the slower-g
         rowing AR cells to persist even when they are susceptible to the same phage.
          This phage-mediated selection is accompanied by enhanced bacterial diversit
         y, further emphasizing the role of phage in shaping the assembly and evoluti
         on of bacterial systems. The mechanism is potentially relevant for any antib
         iotic resistance genetic determinant and has tangible implications for the m
         anagement of bacterial populations via phage therapy.' (1421 chars)
      serialnumber => protected'' (0 chars)
      doi => protected'10.1038/s41467-025-61055-y' (26 chars)
      uid => protected34992 (integer)
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      _versionedUid => protected34992 (integer)modified
      pid => protected124 (integer)