Department Environmental Chemistry

Development of an on-line SPE-LC-MS/MS-method for the determination of pharmaceuticals in the environment

A fully automated on-line solid phase extraction method coupled to liquid chromatography and tandem mass spectrometry using positive electrospray ionization for the determination of pharmaceuticals in wastewater and surface is being developed. The sensitive and selective method allows efficient analysis of a large number of samples needed to represent the spatial and temporal patterns of emerging contaminants in the aquatic environment.


Huntscha, S.; Singer, H. P.; McArdell, C. S.; Frank, C. E.; Hollender, J. (2012) Multiresidue analysis of 88 polar organic micropollutants in ground, surface and wastewater using online mixed-bed multilayer solid-phase extraction coupled to high performance liquid chromatography-tandem mass spectrometry, Journal of Chromatography A, 1268, 74-83, doi:10.1016/j.chroma.2012.10.032, Institutional Repository
Singer, H.; Jaus, S.; Hanke, I.; Lück, A.; Hollender, J.; Alder, A. C. (2010) Determination of biocides and pesticides by on-line solid phase extraction coupled with mass spectrometry and their behaviour in wastewater and surface water, Environmental Pollution, 158(10), 3054-3064, doi:10.1016/j.envpol.2010.06.013, Institutional Repository
Stoob, K.; Singer, H. P.; Goetz, C. W.; Ruff, M.; Mueller, S. R. (2005) Fully automated online solid phase extraction coupled directly to liquid chromatography-tandem mass spectrometry. Quantification of sulfonamide antibiotics, neutral and acidic pesticides at low concentrations in surface waters, Journal of Chromatography A, 1097, 138-147, doi:10.1016/j.chroma.2005.08.030, Institutional Repository