Department Environmental Toxicology

Adverse Outcome Pathways


In collaboration with a high level international expert group we are currently developing a framework to advance adverse outcome pathways (AOPs, www.oecd.org/chemicalsafety/testing/adverse-outcome-pathways-molecular-screening-and-toxicogenomics.htm). The AOP is a conceptual knowledge framework that causally links multiple levels of biological organizations, starting from a direct molecular initiating event, continuing through a number of connected key events and finally arriving to an adverse outcome at a biological level of organization relevant to risk assessment. In the future, we envisage AOPs to be used by environmental protection agencies and regulators when developing and implement environmental policies.

At the research level, we want to use the AOP framework to better understand and predict chronic ecotoxicity generally and chronic fish toxicity specifically. We have identified a behavioral parameter (food intake) as a critical anchor point in fish AOPs and, having established behavioral assays in Utox, we can now focus on the impact on behavior by chemicals and mixtures.

Publications

Burgoon, L. D.; Angrish, M.; Garcia‐Reyero, N.; Pollesch, N.; Zupanic, A.; Perkins, E. (2020) Predicting the probability that a chemical causes steatosis using adverse outcome pathway Bayesian networks (AOPBNs), Risk Analysis, 40(3), 512-523, doi:10.1111/risa.13423, Institutional Repository
Perkins, E. J.; Ashauer, R.; Burgoon, L.; Conolly, R.; Landesmann, B.; Mackay, C.; Murphy, C. A.; Pollesch, N.; Wheeler, J. R.; Zupanic, A.; Scholz, S. (2019) Building and applying quantitative adverse outcome pathway models for chemical hazard and risk assessment, Environmental Toxicology and Chemistry, 38(9), 1850-1865, doi:10.1002/etc.4505, Institutional Repository
Zupanic, A.; Pillai, S.; Coman Schmid, D.; Schirmer, K. (2018) Green algae and networks for adverse outcome pathways, In: Garcia-Reyero, N.; Murphy, C. (Eds.), A systems biology approach to advancing adverse outcome pathways for risk assessment, 133-148, doi:10.1007/978-3-319-66084-4_7, Institutional Repository
Groh, K. J.; Carvalho, R. N.; Chipman, J. K.; Denslow, N. D.; Halder, M.; Murphy, C. A.; Roelofs, D.; Rolaki, A.; Schirmer, K.; Watanabe, K. H. (2015) Development and application of the adverse outcome pathway framework for understanding and predicting chronic toxicity: I. challenges and research needs in ecotoxicology, Chemosphere, 120, 764-777, doi:10.1016/j.chemosphere.2014.09.068, Institutional Repository
Groh, K. J.; Carvalho, R. N.; Chipman, J. K.; Denslow, N. D.; Halder, M.; Murphy, C. A.; Roelofs, D.; Rolaki, A.; Schirmer, K.; Watanabe, K. H. (2015) Development and application of the adverse outcome pathway framework for understanding and predicting chronic toxicity: II. a focus on growth impairment in fish, Chemosphere, 120, 778-792, doi:10.1016/j.chemosphere.2014.10.006, Institutional Repository
Villeneuve, D.; Volz, D. C.; Embry, M. R.; Ankley, G. T.; Belanger, S. E.; Léonard, M.; Schirmer, K.; Tanguay, R.; Truong, L.; Wehmas, L. (2014) Investigating alternatives to the fish early-life stage test: a strategy for discovering and annotating adverse outcome pathways for early fish development, Environmental Toxicology and Chemistry, 33(1), 158-169, doi:10.1002/etc.2403, Institutional Repository
Sturla, S. J.; Boobis, A. R.; FitzGerald, R. E.; Hoeng, J.; Kavlock, R. J.; Schirmer, K.; Whelan, M.; Wilks, M. F.; Peitsch, M. C. (2014) Systems toxicology: from basic research to risk assessment, Chemical Research in Toxicology, 27(3), 314-329, doi:10.1021/tx400410s, Institutional Repository
Volz, D. C.; Belanger, S.; Embry, M.; Padilla, S.; Sanderson, H.; Schirmer, K.; Scholz, S.; Villeneuve, D. (2011) Adverse outcome pathways during early fish development: a conceptual framework for identification of chemical screening and prioritization strategies, Toxicological Sciences, 123(2), 349-358, doi:10.1093/toxsci/kfr185, Institutional Repository

Contact

Prof. Dr. Kristin SchirmerHead of departmentTel. +41 58 765 5266Send Mail

Team members

Dr. Ksenia GrohGroup LeaderTel. +41 58 765 5182Send Mail