Staff

Melanie Fischer

Melanie Fischer

Lab Technician

Department Environmental Toxicology

About Me

My main focus is on the development of alternative methods to reduce the need for animals in (eco)toxicity testing. In particular I work with fish cell lines and zebrafish embryos to predict acute fish lethality and on improving the existing test systems for better prediction capacity.

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Projects

We develop experimental and computational tools to aid in the replacement and reduction of animal testing for environmental risk assessment, specifically for assessments using fish
Fish are the most frequently used vertebrates in regulatory ecotoxicology. Numerous OECD guidelines depend on the use of fish, including OECD 203 (acute fish test), OECD 210 (early life stage toxicity test) and OECD 305 (bioconcentration test)...

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Curriculum Vitae

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Selected publications

Fischer, M.; Belanger, S. E.; Berckmans, P.; Bernhard, M. J.; Bláha, L.; Coman Schmid, D. E.; Dyer, S. D.; Haupt, T.; Hermens, J. L. M.; Hultman, M. T.; Laue, H.; Lillicrap, A.; Mlnaříková, M.; Natsch, A.; Novák, J.; Sinnige, T. L.; Tollefsen, K. E.; von Niederhäusern, V.; Witters, H.; Županič, A.; Schirmer, K. (2019) Repeatability and reproducibility of the RTgill-W1 cell line assay for predicting fish acute toxicity, Toxicological Sciences, 169(2), 353-364, doi:10.1093/toxsci/kfz057, Institutional Repository
Stadnicka-Michalak, J.; Knöbel, M.; Županič, A.; Schirmer, K. (2018) A validated algorithm for selecting non-toxic chemical concentrations, ALTEX: Alternatives to Animal Experimentation, 35(1), 37-50, doi:10.14573/altex.1701231, Institutional Repository
Stadnicka-Michalak, J.; Weiss, F. T.; Fischer, M.; Tanneberger, K.; Schirmer, K. (2018) Biotransformation of benzo [a] pyrene by three rainbow trout (Onchorhynchus mykiss) cell lines and extrapolation to derive a fish bioconcentration factor, Environmental Science and Technology, 52(5), 3091-3100, doi:10.1021/acs.est.7b04548, Institutional Repository
Fischer, S.; Fischer, M.; Schirmer, K.; Werner, I. (2017) Wirkungsorientierte Gewässerüberwachung: Biomonitoring mit Forellen. Studie im Auftrag des Bundesamtes für Umwelt (BAFU). Abschlussbericht 2017, Institutional Repository
Heinlaan, M.; Muna, M.; Knöbel, M.; Kistler, D.; Odzak, N.; Kühnel, D.; Müller, J.; Gupta, G. S.; Kumar, A.; Shanker, R.; Sigg, L. (2016) Natural water as the test medium for Ag and CuO nanoparticle hazard evaluation: an interlaboratory case study, Environmental Pollution, 216, 689-699, doi:10.1016/j.envpol.2016.06.033, Institutional Repository
Strecker, R.; Busquet, F.; Rawlings, J. M.; Belanger, S. E.; Braunbeck, T.; Carr, G. J.; Cenijn, P.; Fochtman, P.; Gourmelon, A.; Hübler, N.; Kleensang, A.; Knöbel, M.; Kussatz, C.; Legler, J.; Lillicrap, A.; Martínez-Jerónimo, F.; Polleichtner, C.; Rzodeczko, H.; Salinas, E.; Schneider, K. E.; Scholz, S.; van den Brandhof, E.-J.; van der Ven, L. T. M.; Walter-Rohde, S.; Weigt, S.; Witters, H.; Halder, M. (2014) OECD validation study to assess intra- and inter-laboratory reproducibility of the zebrafish embryo toxicity test for acute aquatic toxicity testing, Regulatory Toxicology and Pharmacology, 69(3), 496-511, doi:10.1016/j.yrtph.2014.05.018, Institutional Repository
Schirmer, K.; Knoebel, M.; Tanneberger, K. (2013) Gill cells – an alternative to whole fish for toxicity tests, Eawag Newsletter [engl. ed.], 1-7, Institutional Repository
Tanneberger, K.; Knöbel, M.; Busser, F. J. M.; Sinnige, T. L.; Hermens, J. L. M.; Schirmer, K. (2013) Predicting fish acute toxicity using a fish gill cell line-based toxicity assay, Environmental Science and Technology, 47(2), 1110-1119, doi:10.1021/es303505z, Institutional Repository
Knöbel, M.; Busser, F. J. M.; Rico-Rico, Á.; Kramer, N. I.; Hermens, J. L. M.; Hafner, C.; Tanneberger, K.; Schirmer, K.; Scholz, S. (2012) Predicting adult fish acute lethality with the zebrafish embryo: relevance of test duration, endpoints, compound properties, and exposure concentration analysis, Environmental Science and Technology, 46(17), 9690-9700, doi:10.1021/es301729q, Institutional Repository

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Address

E-Mail: melanie.fischer@eawag.ch
Phone: +41 58 765 5233
Fax: +41 58 765 5802
Address: Eawag
Überlandstrasse 133
8600 Dübendorf
Office: BU E12

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