Department Environmental Toxicology

Bioanalytics

In natural waters, chemical pollutants do not act independently but often affect aquatic organisms in complex mixtures or in combination with other environmental stresses. These combinations of different stresses and chemicals strongly increase the complexity for toxicity tests and environmental risk assessment.

For this reason we use accurate and informative chemical and bioanalytical tools (transcriptomics, proteomics, metabolomics), to address the complex interaction of chemicals and biological systems under different environmental conditions.

The goal is a better understanding of the cellular stress response, for an improved model prediction of fate and effect of chemicals and other stressors, ultimately leading to better risk assessment.

Bioanalytics also provides biomarkers of exposure that allow targeting specific effects. This is especially important in effect-directed analysis.

Latest publications

Tierbach, A.; Groh, K. J.; Schoenenberger, R.; Schirmer, K.; Suter, M. J. -F. (2020) Characterization of the mercapturic acid pathway, an important phase II biotransformation route, in a zebrafish embryo cell line, Chemical Research in Toxicology, (9 pp.), doi:10.1021/acs.chemrestox.0c00315, Institutional Repository
Tierbach, A.; Groh, K. J.; Schoenenberger, R.; Schirmer, K.; Suter, M. J. -F. (2020) Biotransformation capacity of zebrafish (Danio rerio) early life stages: functionality of the mercapturic acid pathway, Toxicological Sciences, 176(2), 355-365, doi:10.1093/toxsci/kfaa073, Institutional Repository
Tierbach, A.; Groh, K. J.; Schönenberger, R.; Schirmer, K.; Suter, M. J. -F. (2020) LC-APCI(-)-MS determination of 1-chloro-2,4-dinitrobenzene, a model substrate for glutathione S-transferases, Journal of the American Society for Mass Spectrometry, 31, 467-472, doi:10.1021/jasms.9b00116, Institutional Repository
Tamminen, M.; Betz, A.; Pereira, A. L.; Thali, M.; Matthews, B.; Suter, M. J. -F.; Narwani, A. (2018) Proteome evolution under non-substitutable resource limitation, Nature Communications, 9(1), 4650 (10 pp.), doi:10.1038/s41467-018-07106-z, Institutional Repository
Tierbach, A.; Groh, K. J.; Schönenberger, R.; Schirmer, K.; Suter, M. J. -F. (2018) Glutathione S-transferase protein expression in different life stages of zebrafish (Danio rerio), Toxicological Sciences, 162(2), 702-712, doi:10.1093/toxsci/kfx293, Institutional Repository
Oliveira, I. B.; Groh, K. J.; Schönenberger, R.; Barroso, C.; Thomas, K. V.; Suter, M. J. -F. (2017) Toxicity of emerging antifouling biocides to non-target freshwater organisms from three trophic levels, Aquatic Toxicology, 191, 164-174, doi:10.1016/j.aquatox.2017.07.019, Institutional Repository
Hidasi, A. O.; Groh, K. J.; Suter, M. J. -F.; Schirmer, K. (2017) Clobetasol propionate causes immunosuppression in zebrafish (Danio rerio) at environmentally relevant concentrations, Ecotoxicology and Environmental Safety, 138, 16-24, doi:10.1016/j.ecoenv.2016.11.024, Institutional Repository

Contact

Dr. Marc SuterDeputy Department HeadTel. +41 58 765 5479Send Mail

Team members

Severin AmmannLab TechnicianTel. +41 58 765 6407Send Mail
Ursula LindauerLab TechnicianTel. +41 58 765 5084Send Mail
Sebastian SalzmannLab TechnicianTel. +41 58 765 6461Send Mail
Rene SchoenenbergerLab TechnicianTel. +41 58 765 5105Send Mail

Collaborations