Department Environmental Toxicology

Mechanistic insights into the toxicity of tire particles applying fish cell lines

Tire and road wear particles (TRWP), which are generated by the erosion of tires while driving, have been shown to represent a large part of anthropogenic particles released into the environment. Nevertheless, the potential ecological risk of TRWP and their associated chemicals on aquatic organisms remain largely underinvestigated. Our study aims at determining the toxicity and investigate the mechanisms induced by TRWP and associated chemicals to fish using different rainbow trout cell lines (Oncorhynchus mykiss).

Cover picture: Car/tire picture given by WBCSD in the framework of the TIP, Tire particle electron microscopy from our EPFL partners, Rainbow Trout image created with BioRender



Masset, T.; Ferrari, B. J. D.; Oldham, D.; Dudefoi, W.; Minghetti, M.; Schirmer, K.; Bergmann, A.; Vermeirssen, E.; Breider, F. (2021) In vitro digestion of tire particles in a fish model (Oncorhynchus mykiss): solubilization kinetics of heavy metals and effects of food coingestion, Environmental Science and Technology, 55(23), 15788-15796, doi:10.1021/acs.est.1c04385, Institutional Repository


Prof. Dr. Kristin Schirmer Head of department Tel. +41 58 765 5266 Send Mail

Team Member

Dr. Anna Toso Tel. +41 58 765 6798 Send Mail

In collaboration with

Dr. AlanJames Bergmann Ecotox Centre Tel. +41 58 765 6834 Send Mail
Dr. Benoit Ferrari Ecotox Centre Tel. +41 58 765 5373 Send Mail


World Business Council for Sustainable Development’s (WBCSD) Tire Industry Project (TIP)