Department Fish Ecology and Evolution

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   0 => Snowflake\Publications\Domain\Model\Publicationprototypepersistent entity (uid=9158, pid=124)
      originalId => protected9158 (integer)
      authors => protected'Feulner, P. G. D.; Chain, F. J. J.; Panchal,&n
         bsp;M.; Huang, Y.; Eizaguirre, C.; Kalbe, M.; Lenz, T.&n
         bsp;L.; Samonte, I. E.; Stoll, M.; Bornberg-Bauer, E.; R
         eusch, T. B. H.; Milinski, M.' (277 chars)
      title => protected'Genomics of divergence along a continuum of parapatric population differenti
         ation' (81 chars)
      journal => protected'PLoS Genetics' (13 chars)
      year => protected2015 (integer)
      volume => protected11 (integer)
      issue => protected'2' (1 chars)
      startpage => protected'1' (1 chars)
      otherpage => protected'18' (2 chars)
      categories => protected'' (0 chars)
      description => protected'The patterns of genomic divergence during ecological speciation are shaped b
         y a combination of evolutionary forces. Processes such as genetic drift, loc
         al reduction of gene flow around genes causing reproductive isolation, hitch
         hiking around selected variants, variation in recombination and mutation rat
         es are all factors that can contribute to the heterogeneity of genomic diver
         gence. On the basis of 60 fully sequenced three-spined stickleback genomes, 
         we explore these different mechanisms explaining the heterogeneity of genomi
         c divergence across five parapatric lake and river population pairs varying 
         in their degree of genetic differentiation. We find that divergent regions o
         f the genome are mostly specific for each population pair, while their size 
         and abundance are not correlated with the extent of genome-wide population d
         ifferentiation. In each pair-wise comparison, an analysis of allele frequenc
         y spectra reveals that 25–55% of the divergent regions are consistent with
          a local restriction of gene flow. Another large proportion of divergent reg
         ions (38–75%) appears to be mainly shaped by hitchhiking effects around po
         sitively selected variants. We provide empirical evidence that alternative m
         echanisms determining the evolution of genomic patterns of divergence are no
         t mutually exclusive, but rather act in concert to shape the genome during p
         opulation differentiation, a first necessary step towards ecological speciat
         ion.' (1448 chars)
      serialnumber => protected'1553-7390' (9 chars)
      doi => protected'10.1371/journal.pgen.1004966' (28 chars)
      uid => protected9158 (integer)
      _localizedUid => protected9158 (integer)modified
      _languageUid => protectedNULL
      _versionedUid => protected9158 (integer)modified
      pid => protected124 (integer)
   1 => Snowflake\Publications\Domain\Model\Publicationprototypepersistent entity (uid=9142, pid=124)
      originalId => protected9142 (integer)
      authors => protected'Chain, F. J. J.; Feulner, P. G. D.; Panchal,&n
         bsp;M.; Eizaguirre, C.; Samonte, I. E.; Kalbe, M.; Lenz,
          T. L.; Stoll, M.; Bornberg-Bauer, E.; Milinski, M.
         ; Reusch, T. B. H.' (261 chars)
      title => protected'Extensive copy-number variation of young genes across stickleback population
         s' (77 chars)
      journal => protected'PLoS Genetics' (13 chars)
      year => protected2014 (integer)
      volume => protected10 (integer)
      issue => protected'12' (2 chars)
      startpage => protected'1' (1 chars)
      otherpage => protected'18' (2 chars)
      categories => protected'' (0 chars)
      description => protected'Duplicate genes emerge as copy-number variations (CNVs) at the population le
         vel, and remain copy-number polymorphic until they are fixed or lost. The su
         ccessful establishment of such structural polymorphisms in the genome plays 
         an important role in evolution by promoting genetic diversity, complexity an
         d innovation. To characterize the early evolutionary stages of duplicate gen
         es and their potential adaptive benefits, we combine comparative genomics wi
         th population genomics analyses to evaluate the distribution and impact of C
         NVs across natural populations of an eco-genomic model, the three-spined sti
         ckleback. With whole genome sequences of 66 individuals from populations inh
         abiting three distinct habitats, we find that CNVs generally occur at low fr
         equencies and are often only found in one of the 11 populations surveyed. A 
         subset of CNVs, however, displays copy-number differentiation between popula
         tions, showing elevated within-population frequencies consistent with local 
         adaptation. By comparing teleost genomes to identify lineage-specific genes 
         and duplications in sticklebacks, we highlight rampant gene content differen
         ces among individuals in which over 30% of young duplicate genes are CNVs. T
         hese CNV genes are evolving rapidly at the molecular level and are enriched 
         with functional categories associated with environmental interactions, depic
         ting the dynamic early copy-number polymorphic stage of genes during populat
         ion differentiation.' (1464 chars)
      serialnumber => protected'1553-7390' (9 chars)
      doi => protected'10.1371/journal.pgen.1004830' (28 chars)
      uid => protected9142 (integer)
      _localizedUid => protected9142 (integer)modified
      _languageUid => protectedNULL
      _versionedUid => protected9142 (integer)modified
      pid => protected124 (integer)