Researchers at Eawag recommend setting up a monitoring system for antibiotic resistance in the synthesis report of the National Research Programme NRP 72 Antimicrobial resistance, similar to the wastewater monitoring for...
Researchers at Eawag recommend setting up a monitoring system for antibiotic resistance in the synthesis report of the National Research Programme NRP 72 Antimicrobial resistance, similar to the wastewater monitoring for Sars-CoV-2.
Olokotum, M., Humbert, J. F., Quiblier, C., Okello, W., Semyalo, R., Troussellier, M., … Bernard, C. (2022). Characterization of potential threats from cyanobacterial toxins in Lake Victoria embayments and during water treatment. Toxins, 14(10), 664 (23 pp.). doi:10.3390/toxins14100664, Institutional Repository
Africa’s water needs are often supported by eutrophic water bodies dominated by cyanobacteria posing health threats to riparian populations from cyanotoxins, and Lake Victoria is no exception. In two embayments of the lake (Murchison Bay and Napoleon Gulf), cyanobacterial surveys were conducted to characterize the dynamics of cyanotoxins in lake water and water treatment plants. Forty-six cyanobacterial taxa were recorded, and out of these, fourteen were considered potentially toxigenic (i.e., from the genera Dolichospermum, Microcystis, Oscillatoria, Pseudanabaena and Raphidiopsis). A higher concentration (ranging from 5 to 10 µg MC-LR equiv. L−1) of microcystins (MC) was detected in Murchison Bay compared to Napoleon Gulf, with a declining gradient from the inshore (max. 15 µg MC-LR equiv. L−1) to the open lake. In Murchison Bay, an increase in Microcystis sp. biovolume and MC was observed over the last two decades. Despite high cell densities of toxigenic Microcystis and high MC concentrations, the water treatment plant in Murchison Bay efficiently removed the cyanobacterial biomass, intracellular and dissolved MC to below the lifetime guideline value for exposure via drinking water (<1.0 µg MC-LR equiv. L−1). Thus, the potential health threats stem from the consumption of untreated water and recreational activities along the shores of the lake embayments. MC concentrations were predicted from Microcystis cell numbers regulated by environmental factors, such as solar radiation, wind speed in the N–S direction and turbidity. Thus, an early warning through microscopical counting of Microcystis cell numbers is proposed to better manage health risks from toxigenic cyanobacteria in Lake Victoria.
Bürgmann, H., Egli, A., Endimiani, A., Stephan, R., Tschudin Sutter, S., & Hardt, W. D. (2022). Routes and reservoirs of AMR-determinants & one health AMR-surveillance. Thematic synthesis of the national research programme "Antimicrobial Resistance". Bern: National Research Programme “Antimicrobial Resistance” (NRP 72). , Institutional Repository
New findings enable concrete measures at individual interfaces of AMR spread
The aim of the synthesis process on this topic was to derive recommendations from NRP 72 research that promote the implementation of new findings in practice. The focus of many projects was on the interfaces where antimicrobial resistance (AMR) can spread between humans, animals and the environment. In this One Health context, many research findings of NRP 72 provide the basis for concrete measures to interrupt or restrict transmission chains. In addition to these concrete findings, it has also become apparent that the methods used in NRP 72 research are of great importance: It is a common feature of the projects presented in this thematic synthesis that they have applied new gene sequencing methods, such as whole genome sequencing (WGS), plasmid sequencing and metagenomics. These methods have developed very quickly in the last few years and are a prerequisite for the new insights presented here. [...]