Department Surface Waters - Research and Management

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   0 => Snowflake\Publications\Domain\Model\Publicationprototypepersistent entity (uid=17054, pid=124)
      originalId => protected17054 (integer)
      authors => protected'Bürgmann, H.; Frigon, D.; Gaze, W.; Manaia, C.; Pruden,
          A.; Singer, A. C.; Smets, B.; Zhang, T.' (141 chars)
      title => protected'Water and sanitation: an essential battlefront in the war on antimicrobial r
         esistance' (85 chars)
      journal => protected'FEMS Microbiology Ecology' (25 chars)
      year => protected2018 (integer)
      volume => protected94 (integer)
      issue => protected'9' (1 chars)
      startpage => protected'fiy101 (14 pp.)' (15 chars)
      otherpage => protected'' (0 chars)
      categories => protected'antimicrobial resistance; mitigation; policy; public health; risk assessment
         ; wastewater treatment' (98 chars)
      description => protected'Water and sanitation represents a key battlefront in combating the spread of
          antimicrobial resistance (AMR). Basic water sanitation infrastructure is an
          essential first step to protecting public health, thereby limiting the spre
         ad of pathogens and the need for antibiotics. AMR presents unique human heal
         th risks, meriting new risk assessment frameworks specifically adapted to wa
         ter and sanitation-borne AMR. There are numerous exposure routes to AMR orig
         inating from human waste, each of which must be quantified for its relative 
         risk to human health. Wastewater treatment plants (WWTPs) play a vital role 
         in centralized collection and treatment of human sewage, but there are numer
         ous unresolved questions in terms of the microbial ecological processes occu
         rring within and the extent to which they attenuate or amplify AMR. Research
          is needed to advance understanding of the fate of resistant bacteria and an
         tibiotic resistance genes (ARGs) in various waste management systems, depend
         ing on the local constraints and intended re-use applications. WHO and natio
         nal AMR action plans would benefit from a more holistic 'One Water' understa
         nding. Here we provide a framework for research, policy, practice, and publi
         c engagement aimed at limiting the spread of AMR from water and sanitation i
         n both low-, medium- and high-income countries, alike.' (1346 chars)
      serialnumber => protected'0168-6496' (9 chars)
      doi => protected'10.1093/femsec/fiy101' (21 chars)
      uid => protected17054 (integer)
      _localizedUid => protected17054 (integer)modified
      _languageUid => protectedNULL
      _versionedUid => protected17054 (integer)modified
      pid => protected124 (integer)
   1 => Snowflake\Publications\Domain\Model\Publicationprototypepersistent entity (uid=22266, pid=124)
      originalId => protected22266 (integer)
      authors => protected'Lee, J.; Ju, F.; Maile-Moskowitz, A.; Beck, K.; Maccagna
         n, A.; McArdell, C. S.; Dal Molin, M.; Fenicia, F.;
          Vikesland, P.; Pruden, A.; Stamm, C.; Bürgmann, H.' (224 chars)
      title => protected'Unraveling the riverine antibiotic resistome: the downstream fate of anthrop
         ogenic inputs' (89 chars)
      journal => protected'Water Research' (14 chars)
      year => protected2021 (integer)
      volume => protected197 (integer)
      issue => protected'' (0 chars)
      startpage => protected'117050 (12 pp.)' (15 chars)
      otherpage => protected'' (0 chars)
      categories => protected'antimicrobial resistance; wastewater; river system; metagenomics; transport;
          degradation' (88 chars)
      description => protected'River networks are one of the main routes by which the public could be expos
         ed to environmental sources of antibiotic resistance, that may be introduced
          e.g. via treated wastewater. In this study, we applied a comprehensive inte
         grated analysis encompassing mass-flow concepts, chemistry, bacterial plate 
         counts, resistance gene quantification and shotgun metagenomics to track the
          fate of the resistome (collective antibiotic resistance genes (ARGs) in a m
         icrobial community) of treated wastewater in two Swiss rivers at the kilomet
         er scale. The levels of certain ARGs and the class 1 integron integrase gene
          (<em>intI1</em>) commonly associated with anthropogenic sources of ARGs dec
         reased quickly over short distances (2-2.5 km) downstream of wastewater disc
         harge points. Mass-flow analysis based on conservative tracers suggested thi
         s decrease was attributable mainly to dilution but ARG loadings frequently a
         lso decreased (e.g., 55.0-98.5 % for <em>ermB</em> and <em>tetW</em>) over t
         he longest studied distances (6.8 and 13.7 km downstream). Metagenomic analy
         sis confirmed that ARG of wastewater-origin did not persist in rivers after 
         5 ∼ 6.8 km downstream distance. <em>sul1</em> and <em>intI1</em> levels an
         d loadings were more variable and even increased sharply at 5 ∼ 6.8 km dow
         nstream distance on one occasion. While input from agriculture and in-situ p
         ositive selection pressure for organisms carrying ARGs cannot be excluded, i
         n-system growth of biomass is a more probable explanation. The potential for
          direct human exposure to the resistome of wastewater-origin thus appeared t
         o typically abate rapidly in the studied rivers. However, the riverine aquat
         ic resistome was also dynamic, as evidenced by the increase of certain gene 
         markers downstream, without obvious sources of anthropogenic contamination. 
         This study provides new insight into drivers of riverine resistomes and pinp
         oints key monitoring targets indicative of where human sources and exposures
          are likely to be most a...' (2005 chars)
      serialnumber => protected'0043-1354' (9 chars)
      doi => protected'10.1016/j.watres.2021.117050' (28 chars)
      uid => protected22266 (integer)
      _localizedUid => protected22266 (integer)modified
      _languageUid => protectedNULL
      _versionedUid => protected22266 (integer)modified
      pid => protected124 (integer)
   2 => Snowflake\Publications\Domain\Model\Publicationprototypepersistent entity (uid=26112, pid=124)
      originalId => protected26112 (integer)
      authors => protected'Bürgmann,&nbsp;H.; Egli,&nbsp;A.; Endimiani,&nbsp;A.; Stephan,&nbsp;R.; Tsc
         hudin Sutter,&nbsp;S.; Hardt,&nbsp;W.-D.' (116 chars)
      title => protected'Routes and reservoirs of AMR-determinants &amp; one health AMR-surveillance.
          Thematic synthesis of the national research programme "Antimicrobial Resist
         ance"' (157 chars)
      journal => protected'' (0 chars)
      year => protected2022 (integer)
      volume => protected0 (integer)
      issue => protected'' (0 chars)
      startpage => protected'53&nbsp;p' (9 chars)
      otherpage => protected'' (0 chars)
      categories => protected'' (0 chars)
      description => protected'New findings enable concrete measures at individual interfaces of AMR spread
         <br /><br />The aim of the synthesis process on this topic was to derive rec
         ommendations from NRP 72 research that promote the implementation of new fin
         dings in practice. The focus of many projects was on the interfaces where an
         timicrobial resistance (AMR) can spread between humans, animals and the envi
         ronment. In this One Health context, many research findings of NRP 72 provid
         e the basis for concrete measures to interrupt or restrict transmission chai
         ns.<br />In addition to these concrete findings, it has also become apparent
          that the methods used in NRP 72 research are of great importance: It is a c
         ommon feature of the projects presented in this thematic synthesis that they
          have applied new gene sequencing methods, such as whole genome sequencing (
         WGS), plasmid sequencing and metagenomics. These methods have developed very
          quickly in the last few years and are a prerequisite for the new insights p
         resented here. [...]' (1008 chars)
      serialnumber => protected'' (0 chars)
      doi => protected'' (0 chars)
      uid => protected26112 (integer)
      _localizedUid => protected26112 (integer)modified
      _languageUid => protectedNULL
      _versionedUid => protected26112 (integer)modified
      pid => protected124 (integer)
   3 => Snowflake\Publications\Domain\Model\Publicationprototypepersistent entity (uid=8101, pid=124)
      originalId => protected8101 (integer)
      authors => protected'Berendonk,&nbsp;T.&nbsp;U.; Manaia,&nbsp;C.&nbsp;M.; Merlin,&nbsp;C.; Fatta-
         Kassinos,&nbsp;D.; Cytryn,&nbsp;E.; Walsh,&nbsp;F.; Bürgmann,&nbsp;H.; Sør
         um,&nbsp;H.; Norström,&nbsp;M.; Pons,&nbsp;M.-N.; Kreuzinger,&nbsp;N.; Huov
         inen,&nbsp;P.; Stefani,&nbsp;S.; Schwartz,&nbsp;T.; Kisand,&nbsp;V.; Baquero
         ,&nbsp;F.; Martinez,&nbsp;J.&nbsp;L.' (340 chars)
      title => protected'Tackling antibiotic resistance: the environmental framework' (59 chars)
      journal => protected'Nature Reviews Microbiology' (27 chars)
      year => protected2015 (integer)
      volume => protected13 (integer)
      issue => protected'5' (1 chars)
      startpage => protected'310' (3 chars)
      otherpage => protected'317' (3 chars)
      categories => protected'' (0 chars)
      description => protected'Antibiotic resistance is a threat to human and animal health worldwide, and 
         key measures are required to reduce the risks posed by antibiotic resistance
          genes that occur in the environment. These measures include the identificat
         ion of critical points of control, the development of reliable surveillance 
         and risk assessment procedures, and the implementation of technological solu
         tions that can prevent environmental contamination with antibiotic resistant
          bacteria and genes. In this Opinion article, we discuss the main knowledge 
         gaps, the future research needs and the policy and management options that s
         hould be prioritized to tackle antibiotic resistance in the environment.' (680 chars)
      serialnumber => protected'1740-1526' (9 chars)
      doi => protected'10.1038/nrmicro3439' (19 chars)
      uid => protected8101 (integer)
      _localizedUid => protected8101 (integer)modified
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      _versionedUid => protected8101 (integer)modified
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