Department Environmental Microbiology

Bacterial tolerance to antibiotics – individual and collective effects

Antibiotics play an essential role for treating bacterial infections in humans and animals, and treatment failure is potentially fatal for infected hosts. A lot of attention is currently given to bacteria that are genetically resistant to antibiotics and can thereby lead to treatment failure. However, bacteria can evade treatment even if they are not genetically resistant. Specific growth conditions, or interactions with other bacterial strains, can render bacterial cells insensitive to the effects of antibiotics. Understanding how bacteria can evade antibiotics, and how antibiotics can be used in a more effective manner, is important both from a scientific as well as from an applied perspective. We are quantifying how antibiotics impact growth and survival of individual bacterial cells, and how these impacts depend on the growth condition and the composition of the bacterial community.

Publications to this project:

Ocampo, P. S.; Lázár, V.; Papp, B.; Arnoldini, M.; zur Wiesch, P. A.; Busa-Fekete, R.; Fekete, G.; Pál, C.; Ackermann, M.; Bonhoeffer, S. (2014) Antagonism between bacteriostatic and bactericidal antibiotics is prevalent, Antimicrobial Agents and Chemotherapy, 58(8), 4573-4582, doi:10.1128/AAC.02463-14, Institutional Repository
Arnoldini, M.; Vizcarra, I. A.; Peña-Miller, R.; Stocker, N.; Diard, M.; Vogel, V.; Beardmore, R. E.; Hardt, W.-D.; Ackermann, M. (2014) Bistable expression of virulence genes in Salmonella leads to the formation of an antibiotic-tolerant subpopulation, PLoS Biology, 12(8), 1-8, doi:10.1371/journal.pbio.1001928, Institutional Repository