Department Environmental Toxicology

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   0 => Snowflake\Publications\Domain\Model\Publicationprototypepersistent entity (uid=21778, pid=124)
      originalId => protected21778 (integer)
      authors => protected'Fitzgerald, J. A.; Könemann, S.; Krümpelmann, L.; Žup
         anič, A.; vom Berg, C.' (109 chars)
      title => protected'Approaches to test the neurotoxicity of environmental contaminants in the ze
         brafish model - from behavior to molecular mechanisms' (129 chars)
      journal => protected'Environmental Toxicology and Chemistry' (38 chars)
      year => protected2021 (integer)
      volume => protected40 (integer)
      issue => protected'4' (1 chars)
      startpage => protected'989' (3 chars)
      otherpage => protected'1006' (4 chars)
      categories => protected'neurotoxicity; behavioral toxicology; ecotoxicology; toxicity mechanism; tel
         eost' (80 chars)
      description => protected'The occurrence of neuroactive chemicals in the aquatic environment is on the
          rise and poses a potential threat to aquatic biota of currently unpredictab
         le outcome. In particular, subtle changes caused by these chemicals to an or
         ganism's sensation or behavior are difficult to tackle with current test sys
         tems that focus on rodents or with in vitro test systems omitting whole anim
         al responses. In recent years, zebrafish (<em>Danio rerio)</em> have become 
         a popular model organism for toxicological studies and testing strategies, s
         uch as the standardized use of zebrafish early life stages in the OECD guide
         line 236. In terms of neurotoxicity, the zebrafish provides a powerful model
          to investigate changes to the nervous system from several different angles,
          offering the ability to tackle the mechanisms of action of chemicals in det
         ail. The mechanistic understanding gained through the analysis of this model
          species provides a good basic knowledge of how neuroactive chemicals might 
         interact with a teleost nervous system. Such information can help infer pote
         ntial effects occurring to other species exposed to neuroactive chemicals in
          their aquatic environment and predicting potential risks of a chemical for 
         the aquatic ecosystem. In the present article, we highlight approaches rangi
         ng from behavioral to structural, functional and molecular analysis of the l
         arval zebrafish nervous system, providing a holistic view of potential neuro
         toxic outcomes.' (1459 chars)
      serialnumber => protected'0730-7268' (9 chars)
      doi => protected'10.1002/etc.4951' (16 chars)
      uid => protected21778 (integer)
      _localizedUid => protected21778 (integer)modified
      _languageUid => protectedNULL
      _versionedUid => protected21778 (integer)modified
      pid => protected124 (integer)
   1 => Snowflake\Publications\Domain\Model\Publicationprototypepersistent entity (uid=19264, pid=124)
      originalId => protected19264 (integer)
      authors => protected'Fitzgerald,&nbsp;J.&nbsp;A.; Kirla,&nbsp;K.&nbsp;T.; Zinner,&nbsp;C.&nbsp;P.
         ; vom Berg,&nbsp;C.&nbsp;M.' (103 chars)
      title => protected'Emergence of consistent intra-individual locomotor patterns during zebrafish
          development' (88 chars)
      journal => protected'Scientific Reports' (18 chars)
      year => protected2019 (integer)
      volume => protected9 (integer)
      issue => protected'' (0 chars)
      startpage => protected'13647 (14 pp.)' (14 chars)
      otherpage => protected'' (0 chars)
      categories => protected'' (0 chars)
      description => protected'The analysis of larval zebrafish locomotor behavior has emerged as a powerfu
         l indicator of perturbations in the nervous system and is used in many field
         s of research, including neuroscience, toxicology and drug discovery. The be
         havior of larval zebrafish however, is highly variable, resulting in the use
          of large numbers of animals and the inability to detect small effects. In t
         his study, we analyzed whether individual locomotor behavior is stable over 
         development and whether behavioral parameters correlate with physiological a
         nd morphological features, with the aim of better understanding the variabil
         ity and predictability of larval locomotor behavior. Our results reveal that
          locomotor activity of an individual larva remains consistent throughout a g
         iven day and is predictable throughout larval development, especially during
          dark phases, under which larvae demonstrate light-searching behaviors and i
         ncreased activity. The larvae’s response to startle-stimuli was found to b
         e unpredictable, with no correlation found between response strength and loc
         omotor activity. Furthermore, locomotor activity was not associated with phy
         siological or morphological features of a larva (resting heart rate, body le
         ngth, size of the swim bladder). Overall, our findings highlight the areas o
         f intra-individual consistency, which could be used to improve the sensitivi
         ty of assays using zebrafish locomotor activity as an endpoint.' (1431 chars)
      serialnumber => protected'2045-2322' (9 chars)
      doi => protected'10.1038/s41598-019-49614-y' (26 chars)
      uid => protected19264 (integer)
      _localizedUid => protected19264 (integer)modified
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      _versionedUid => protected19264 (integer)modified
      pid => protected124 (integer)