Département Toxicologie de l’environnement

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      originalId => protected35005 (integer)
      authors => protected'Revel, M.; Groh, K.; Bertoli, J.; Degeratu, M.-O.; Fisch
         er, M.; Fischer, S.; Hoekman, J.; Jozef, B.; Li, R.
         ; Mosimann, S. L.; vom Berg, C.; Županič, A.; Truffer,
          B.; Schirmer, K.' (255 chars)
      title => protected'Development of the fish invitrome for animal-free environmental risk assessm
         ent of chemicals' (92 chars)
      journal => protected'Environmental Toxicology and Chemistry' (38 chars)
      year => protected2025 (integer)
      volume => protected44 (integer)
      issue => protected'9' (1 chars)
      startpage => protected'2648' (4 chars)
      otherpage => protected'2658' (4 chars)
      categories => protected'new approach methodologies; rainbow trout cell lines; toxicity testing; soci
         o-technical approach; co-design with stakeholders' (125 chars)
      description => protected'Given the need to reduce animal testing for environmental risk assessment, w
         e aim to develop a fish invitrome, an alternative fish modular framework cap
         able of predicting chemical toxicity in fish without the use of animals. The
          central module of the framework is the validated RTgill-W1 cell line assay 
         that predicts fish acute toxicity of chemicals (Organisation for Economic Co
         -operation and Development test guideline 249). Expanding towards prediction
          of chronic toxicity, the fish invitrome includes two other well-advanced mo
         dules for chemical bioaccumulation/biotransformation and inhibition of fish 
         growth. This framework is expected to continuously evolve with the developme
         nt of modules that predict, for instance, neurotoxicity and reproductive tox
         icity. We envisage the fish invitrome framework becoming part of the broader
          academic field of new approach methodologies (NAMs), where it will remain f
         lexible and open to integration of new developments from research groups aro
         und the world. To accelerate the development and uptake of this framework, w
         e strive for transdisciplinarity, integrating both natural and social scienc
         es, along with broader stakeholder interactions. A stepwise socio-technical 
         approach was chosen, where mainstreaming the fish invitrome involves progres
         sive adoption across various ecotoxicological contexts. The framework will b
         e codesigned with stakeholders from academia, industry, and regulatory bodie
         s. Rather than aiming for immediate regulatory acceptance, this approach aim
         s to build trust and familiarity with fish cell line–based testing among s
         takeholders. By doing so, it encourages broader use of the framework in prac
         tical applications while gradually overcoming institutional, cultural, and t
         echnical barriers. Additionally, establishing a clear roadmap for mainstream
         ing the fish invitrome will help identify and address challenges to its upta
         ke, ensuring a smoother transition<br />to nonorganismal testing methodologi
         es.' (1979 chars)
      serialnumber => protected'0730-7268' (9 chars)
      doi => protected'10.1093/etojnl/vgaf028' (22 chars)
      uid => protected35005 (integer)
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