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array(2 items)
   0 => Snowflake\Publications\Domain\Model\Publicationprototypepersistent entity (uid=34703, pid=124)
      originalId => protected34703 (integer)
      authors => protected'Baumgartner, S.; Salvisberg, M.; Schmidhalter, P.; Julian,&nb
         sp;T. R.; Ort, C.; Singer, H.' (120 chars)
      title => protected'Insights into respiratory illness at the population level through parallel a
         nalysis of pharmaceutical and viral markers in wastewater' (133 chars)
      journal => protected'Nature Water' (12 chars)
      year => protected2025 (integer)
      volume => protected3 (integer)
      issue => protected'' (0 chars)
      startpage => protected'580' (3 chars)
      otherpage => protected'589' (3 chars)
      categories => protected'' (0 chars)
      description => protected'Wastewater as a medium contains information on both circulating pathogens an
         d drug consumption at the population level. This study combines tracking of 
         respiratory viruses and quantification of pharmaceuticals as untargeted indi
         cators of symptoms related to acute respiratory infections and influenza-lik
         e illnesses such as coughing, fever and pain. From January 2021 to June 2024
         , raw wastewater samples from ten locations covering 23% of the Swiss popula
         tion were analysed. This encompassed 15 pharmaceuticals and four priority re
         spiratory viruses including severe acute respiratory syndrome coronavirus vi
         rus-2 (SARS-CoV-2), respiratory syncytial virus (RSV), influenza A and influ
         enza B viruses. The pharmaceutical compounds dextromethorphan, pheniramine, 
         clarithromycin, acetaminophen and codeine showed a strong correlation with r
         espiratory virus loads in wastewater. This enabled the estimation of pathoge
         n-specific and cumulative symptom treatment in the population. In 2021 and 2
         024, notable increases in pharmaceutical loads without corresponding increas
         es in viral loads signalled high community symptoms linked to unsurveilled p
         athogens. This study demonstrates that pharmaceutical surveillance can infor
         m respiratory disease burden and highlights the value of integrated surveill
         ance for assessing emerging public health threats beyond those routinely mon
         itored.' (1375 chars)
      serialnumber => protected'' (0 chars)
      doi => protected'10.1038/s44221-025-00437-4' (26 chars)
      uid => protected34703 (integer)
      _localizedUid => protected34703 (integer)modified
      _languageUid => protectedNULL
      _versionedUid => protected34703 (integer)modified
      pid => protected124 (integer)
   1 => Snowflake\Publications\Domain\Model\Publicationprototypepersistent entity (uid=34768, pid=124)
      originalId => protected34768 (integer)
      authors => protected'Gan, C.; Pitton, M.; de Korne-Elenbaas, J.; Cobuccio, L.
         ; Cassini, A.; Ort, C.; Julian, T. R.' (133 chars)
      title => protected'Retrospective wastewater tracking of measles outbreak in western Switzerland
          in winter 2024' (91 chars)
      journal => protected'Environmental Science and Technology Letters' (44 chars)
      year => protected2025 (integer)
      volume => protected12 (integer)
      issue => protected'6' (1 chars)
      startpage => protected'689' (3 chars)
      otherpage => protected'694' (3 chars)
      categories => protected'measles; wastewater surveillance; digital PCR; outbreak detection; strain di
         fferentiation' (89 chars)
      description => protected'Measles outbreaks remain a significant public health challenge, despite high
          vaccination coverage in many regions. Wastewater-based surveillance (WBS) o
         ffers a noninvasive and community-level approach to monitoring the circulati
         on of pathogens, including the measles virus. Here, we retrospectively appli
         ed a duplex digital PCR assay to distinguish between wild-type and vaccine s
         trains of the measles virus in wastewater samples available from an existing
          national WBS program. Samples originated from the wastewater treatment plan
         t serving the Lausanne city catchment area, where an outbreak occurred befor
         e spreading to the broader Canton Vaud region. Despite high vaccination rate
         s, viral loads of the measles wild type were detected during the first trans
         mission event involving 21 cases identified within a week. However, viral lo
         ads were no longer detectable after the initial 21 cases, despite an additio
         nal 30 cases reported in the following 3 weeks, possibly due to lower incide
         nce rate or location outside the catchment. Measles vaccine strain was not d
         etected during the outbreak. Our results demonstrate the complementarity of 
         WBS with clinical surveillance and suggest its potential as an early warning
          system for measles and other vaccine-preventable diseases. Further improvem
         ents in the assay sensitivity and integration with epidemiological data coul
         d enhance the utility of WBS for outbreak detection and control.' (1432 chars)
      serialnumber => protected'' (0 chars)
      doi => protected'10.1021/acs.estlett.5c00244' (27 chars)
      uid => protected34768 (integer)
      _localizedUid => protected34768 (integer)modified
      _languageUid => protectedNULL
      _versionedUid => protected34768 (integer)modified
      pid => protected124 (integer)